reSearch Magazine Features

8/2/10 :: New Mouse Model of DMD More Accurately Mimics Human Disease

Therapies to treat Duchenne muscular dystrophy may sooner progress toward clinical trials thanks to a more realistic mouse model that mimics the human disease better than existing models.  The new framework is detailed in a Nationwide Children’s Hospital study that appears in Science Translational Medicine.

7/21/10 :: Many Substance-Using Kids May Be Willing to Quit

A substantial portion of adolescents who are admitted substance users may be willing to change their behavior regarding their alcohol or illicit drug use, according to research from Nationwide Children’s Hospital.
 

7/21/10 :: Survival Strategy: Bacteria Repairs Its DNA

Investigators at Nationwide Children’s Hospital have identified genes critical in helping bacteria bypass the body’s first line of defense. Epithelial cells line cavities and surfaces of internal and external organs and structures throughout the body.  Because they comprise the outer surface, epithelial cells serve as the first line of defense against microorganisms. Yet mechanisms these cells use to control bacterial diseases are poorly understood.
 

7/21/10 :: Hepatitis C Virus Enlists Different Escape Routines

Findings from Nationwide Children’s are adding to the belief that the Hepatitis C virus, the virus that leads to the contagious liver disease Hepatitis C, is a crafty pathogen. The virus seems to enlist different escape routines in response to different types of immune cells.
 

7/21/10 :: It May Be Clinically Acceptable to Delay Growth Factor Treatment in Children Post-Chemotherapy

Treating children with growth factors as late as five days after they receive a bone marrow or blood stem cell transplant may result in substantial cost savings and still be as clinically beneficial as treating patients one day after transplantation. These findings are from a Nationwide Children’s Hospital study appearing in Pediatric Blood & Cancer, the first study to examine whether delayed administration in pediatrics affects engraftment time.
 

7/15/2010 :: Could Waiting Two Minutes Improve How Newborns Recover from Heart Surgery?

A newly funded study is set to determine whether waiting two minutes to clamp a newborn’s umbilical cord after delivery could improve how well he or she recovers from corrective heart surgery.
 

6/16/2010 :: Sickle Cell Patients Should Be Better Monitored for Constipation Prevention

Not all patients with sickle cell disease receive laxatives after being treated with narcotics, despite recommendations from a collaborative panel of pediatric experts.  These are the findings from a Nationwide Children’s Hospital study examining patients from 29 pediatric hospitals, and appearing in Pediatric Blood & Cancer.
 

6/9/2010 :: New Potential Autism Susceptibility Genes Identified

Several newly-identified genes may make children more susceptible to developing autism, according to a study from the Autism Genome Project, an international consortium that includes Nationwide Children’s Hospital. These second-phase results appear in Nature.
 

6/8/2010 :: Nationwide Children’s Hospital Receives Palliative Care Research Grant

Cynthia Gerhardt, PhD, awarded grant for research to improve care of seriously ill patients
 

6/3/2010 :: Investing in Science; A Family’s Donation to Research Leads to National Funding

Nationwide Children’s Dr. Chris Pierson and the Foye Family from New Jersey have something in common: a focus on finding new treatments for rare muscle diseases known as centronuclear myopathies.


6/3/2010 :: Feeding Neonatal Mice with Growth-Factor-Fortified Formula Helps Protect Against a Damaging Intestinal Disease Seen in Humans

Findings support the concept of clinical administration of HB-EGF to patients with or at-risk for developing NEC, a severely damaging gastrointestinal disease