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| Education |
| 1998 |
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Ph.D. |
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Neuroscience |
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The Ohio State University, Columbus, Ohio |
| 1972 |
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M.D. |
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Medicine |
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Hacettepe University Medical School, Ankara, Turkey |
| Professional Experience |
| 2005- PRES |
Professor of Neurology and Pediatrics, The Research Institute at Nationwide Children's Hospital, Neuromuscular Program, Director, Neuromuscular Pathology |
| 1999- PRES |
Professor of Neurology, Department of Neurology, Ohio State University College of Medicine |
| 1999- 2005 |
Director of the Clinical and Experimental Neuromuscular Disease Laboratories, Division of Neuromuscular Disease, Department of Neurology, Ohio State University Hospitals |
| 1983- 1999 |
Associate Professor or Neurology, Department of Neurology, Ohio State University College of Medicine |
| 1986- 1987 |
Visiting Scientist, Bio-Architectonics Center, Case Western Reserve University, Cleveland, Ohio |
| 1978- 1983 |
Assistant Professor, Department of Neurology, Ohio State University College of Medicine |
Research Interests
Dr. Zarife Sahenk is currently Professor of Neurology and Pediatrics and Director of the Clinical and Experimental Neuromuscular Pathology at The Research Institute at Nationwide Children's Hospital. A primary goal of her research program is to gain a detailed understanding of the anatomical and molecular basis of hereditary peripheral neuropathies. Particular emphasis is placed on the role of trophic factors secreted by Schwann cells in regeneration-associated myelination. The role of neurotrophin-3 in nerve regeneration in patients and animal models of Charcot-Marie-Tooth (CMT) is currently being investigated. These studies are relevant to understanding the mechanism of axonal loss and impaired regeneration in CMT disorders and developing rational therapies to promote nerve repair.
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| Selected Publications |
| Rodino-Klapac LR, Montgomery CL, Bremer WG, Shontz KM, Malik V, Davis N, Sprinkle S, Campbell KJ, Sahenk Z, Clark KR, Walker CM, Mendell JR, Chicoine LG.Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery.Mol Ther. 2010;18(1):109-17. PubMed ID: 19904237 |
| Kota J, Handy CR, Haidet AM, Montgomery CL, Eagle A, Rodino-Klapac LR, Tucker D, Shilling CJ, Therlfall WR, Walker CM, Weisbrode SE, Janssen PM, Clark KR, Sahenk Z, Mendell JR, Kaspar BK. Follistatin gene delivery enhances muscle growth and strength in nonhuman primates.Sci Transl Med.2009;1(6):6ra15. PubMed ID: 20368179 |
| Mendell JR, Rodino-Klapac LR, Rosales-Quintero X, Kota J, Coley BD, Galloway G, Craenen JM, Lewis S, Malik V, Shilling C, Byrne BJ, Conlon T, Campbell KJ, Bremer WG, Viollet L, Walker CM, Sahenk Z, Clark KR. Limb-girdle muscular dystrophy type 2D gene therapy restores alpha-sarcoglycan and associated proteins.Ann Neurol. 2009;66(3):290-7. PubMed ID: 19798725 |
| Martin PT, Xu R, Rodino-Klapac LR, Oglesbay E, Camboni M, Montgomery CL, Shontz K, Chicoine LG, Clark KR, Sahenk Z, Mendell JR, Janssen PM. Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice.Am J Physiol Cell Physiol. 2009;296(3):C476-88. PubMed ID: 19109526 |
| Tsao CY, Mendell J, Sahenk Z, Rusin J, Boue D. Hypotonia, weakness, and pontocerebellar hypoplasia in siblings. Semin Pediatr Neurol. 2008;15(4):151-3. PubMed ID: 19073313 |
| Sahenk Z, Oblinger J, Edwards C. Neurotrophin-3 deficient Schwann cells impair nerve regeneration. Exp Neurol. 2008 Aug;212(2):552-556. PubMed ID: 18511043 |
Zhang X, CY, Sahenk Z, Shy ME, Meisler MH, Li J. Mutation of FIG4 causes a rapidly progressive, asymmetric neronal degenernation. Brain 2008;131(Pt8):1990-2001 PubMed ID: 18556664 |
| Sahenk Z. Neurotrophins and peripheral neuropathies. Brain Pathol. 2006 Oct;16(4):311-9. PubMed ID: 17107601 |
Sahenk Z, Nagaraja H, McCracken BS, King WM, Freimer ML, Cedarbaum JM, Mendell JR. NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients. Neurology 2005;65(5):681-689 PubMed ID: 16157899 |
Abrams CK, Freidin M, Bukauskas F, Dobrenis K, Bargiello TA, Verselis VK, Bennett MVL, Chen L, and Sahenk Z. Pathogenesis of CMTX: Different side effects of two mutations in connexin 32. J Neurosci 2003;23(33):10548-58 PubMed ID: 14627639 |
| Sahenk Z, Serrano-Munuera C, Chen L, Kakabadze I: Evidence for impaired regeneration in PMP22duplication: Studies in nerve xenografts. J Periph Nerv Syst 8(2): 116-127, 2003. PubMed ID: 12795716 |
Haney CA, Sahenk Z, Li C, Lemmon VP, Roder J, Trapp BD. Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and required for axonal survival. J Cell Biol 1999; 146:1173-184 PubMed ID: 10477768 |
Sahenk Z, Mendell JR. Alterations in nodes of Ranvier and Schmidt-Lanterman clefts in CMT neuropathies. Ann NY Acad Sci 1999;883:305-512 PubMed ID: 10586286 |
Sahenk Z, Chen L, Mendell JR. The effects of PMP22 duplication and deletions on the axonal cytoskeleton. Ann Neurol 1999;45:16-24 PubMed ID: 9894872 |
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