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MONTANARO LABORATORY
My laboratory is interested in muscle regeneration and in the development of cell-based therapies for muscular dystrophy disorders, in particular Duchenne Muscular Dystrophy. On one hand, we are studying in vitro models of muscle regeneration to identify genes and pathways that are important for the activation of muscle stem cells and their participation in muscle repair. We are using a combination of gene expression arrays and RNA interference to identify and characterize genes of interest. On the other hand, we have identified stem cells from the adult skin that are able to participate in muscle repair following vascular delivery. We are now optimizing the transplantation parameters and further characterizing these cells to improve the efficiency with which they repair dystrophic muscles.
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| Education |
| 1999 |
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Ph.D. |
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Neurobiology |
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McGill University, Montreal, Quebec, Canada |
| 1991 |
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BSc. |
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Neurobiology |
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McGillUniveristy, Montreal, Quebec, Canada |
| Professional Experience |
| 2005- PRES |
Assistant Professor, Department of Pediatrics, The Research Institute at Nationwide Children's Hospital and Ohio State University |
| 1999- 2005 |
HHMI Post-doctoral fellow, Harvard Medical School and Children's Hospital |
| Selected Publications |
| Kaspar, R.W., Allen, H.D. and Montanaro F. (2009). Current understanding and management for dilated cardiomyopathy in Duchenne and Becker muscular dystrophy. Journal of the American Academy of Nurse Practitioners,21(5):241-9 PubMed ID: 19432907 |
| Montanaro F. and Martin, P.T. (2009). Defective glycosylation of dystroglycan in muscular dystrophy and cancer. In “Post-translational Modifications in Health and Disease”. Editor Cecilio Vidal Moreno. Protein Reviews Series. Series Editor Zouhair Atassi, M., in press. |
| Liadaki K., Montanaro F. and Kunkel L.M. Cellular-mediated delivery: the intersection between regenerative medicine and genetic therapy.In“Duchenne muscular dystrophy: Advances in therapeutics”. Editors Rando T. and Chamberlain J. 2006. |
| Guyon J.R., Mosley A.N., Jun S.J., Montanaro F., Steffen L.S., Zhou Y., Nigro V., Zon L.I., Kunkel L.M. (2005) Delta-sarcoglycan is required for early Zebrafish muscle organization. Exp. Cell Res. 304: 105-115. PubMed ID: 15707578 |
| Montanaro F., Liadaki K., Schienda J., Flint A., Gussoni E., Kunkel L.M. (2004) Demystifying SP cell purification: viability, yield and phenotype are defined by isolation parameters. Exp. Cell Res. 298: 144-154 PubMed ID: 15242769 |
| Montanaro F., Liadaki K., Schienda J., Flint A., Gussoni E., Kunkel L.M., Demystifying SP cell purification: viability, yield and phenotype are defined by isolation parameters. Exp. Cell Res. 298: 144-5154, 2004. |
| Tomczak K.K., Marinescu V.D., Ramoni M.F., Sanoudou D., Montanaro F., Han M., Kohane I., Beggs A.H., Expression profiling and functional classification of genes involved in myogenic differentiation. FASEB J. 18: 403-405, 2004. |
| Montanaro F., Liadaki K., Volinski J., Flint A., Kunkel L.M., Skeletal muscle engraftment potential of adult mouse skin side population cells. Proc. Natl. Academy of Science. 100: 9336-9341, 2003. |
Montanaro F. and Carbonetto S. (2003) Targeting dystroglycan in the brain. Neuron 37(2):193-196. |
| Montanaro F., Lindenbaum M.H., Carbonetto S., dystroglycan is a laminin receptor involved in extracellular matrix assembly on myotubes and muscle cell viability. Journal of Cell Biology. 145: 1325-1340, 1999. |
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